Physics 581-002 and 480-001
Tuesdays and Thursdays from 4 to 5:15 in room 5.
The main textbook is
Physical Biology of the Cell (2nd Edition) by Phillips and
The UNM bookstore and Amazon sell physical copies of this book.
A pdf of it is available for free on the website
We also will use my class notes.
The book Introduction to Thermal Physics
by Daniel Schroeder is excellent as is the book
Molecular Driving Forces by Ken Dill and
Sarina Bromberg. Both are available for free on the website
Two pages from Physical Mathematics
on Lagrange multipliers.
An article on editing out redundant codons is
Janie Rae Byrum, Rebecca Hartley, and Keith Lidke
have pointed out these articles on how cells use proteins and small
noncoding RNAs to get RNA to fold correctly:
article on RNA folding.
minireview of RNA chaperones.
review of RNA Chaperones, RNA Annealers and RNA Helicases.
review of chaperone proteins.
link to a website that predicts how a given strand of RNA or DNA
article on DNA and RNA hairpins teased by optical tweezers.
Video of laminar-flow demo.
27 October Cedric Clayrat on CRISPR-Cas9
1 November Keith Lidke on Fluorescence Nanoscopy
10 November Fu-Sen Liang on Cell Control
6 December Marjolein Meddens
Title: Biophysical techniques to study mechanosensory podosomes in immune cells
Abstract: Various immune cells such as macrophages and dendritic
cells use cytoskeletal structures called podosomes to sense and
explore their environment. In this talk I will show how biophysical
methods such as super-resolution microscopy, image correlation
spectroscopy and FRET have deepened our understanding of the structure
and function of podosomes.
8 December Laurel Sillerud
Title: Alzheimer's Disease: The long, dark tea-time of the Brain
The enzyme that cuts and rejoins DNA is
Some 2500 repeats of TTAGGG at the ends of human chromosomes
Errata in PBoC2:
In equations (3.18) & (3.19), D should be 6D.
Last autumn, the course was on
Mondays and Wednesdays at 4:30 in room 184.
Here are some of its links:
Here's a video
of the demonstration
in which I poured sulfuric acid onto some sugar
in a beaker.
On YouTube it's here.
Here are the class notes.
Here are my notes on probability and statistics.
gorgeous image of the genetic code.
Here's the article Flippin' lipids about
flippase, floppase, and scramblase.
Here are some chapters on neurons: chapter
chapter four, and
Here's a paper that Gabriel Sandoval found that says that mitochondria
can reproduce in axons.
Here's a video
about the packing of DNA that Matt Koppa found. The YouTube website
also has videos of other topics in molecular biology.
Here are chapters 10 and 11 of MBoC5.
Here's a write-up of mine on neurons.
I do not guarrantee the part about action potentials, which I wrote up
some years ago, but it might be right.
Here's a paper of mine on membrane
Here's some info on cycles on cycles of reactions.
Here's chapter 14 of MBoC6 on mitochondria.
Here's a link to Harvard's
Inner Life of the Cell videos.
Link to my lecture on on the
Fisher information matrix, the Cramer-Rao lower bound, and
Kolmogorov's theorem and test.
Also available on YouTube.
Links of Mr. Koppa's talk on
exercise, on genetic
and (full article) on
Homework due Wednesday 26 August 2015:
Derive equation (1.5) of the class notes from equation (1.4).
Homework due Wednesday 9 September 2015:
Compute the number of negative ions that lie just below the surface of
a cell's membrane if the radius of the cell is 1 micron
and the electrostatic potential across the membrane is - 50 mV.